Knockdown of lncRNA LSINCT5 suppresses growth and metastasis of human glioma cells via up-regulating miR-451
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miR-451 Up-regulation, Induce Erythroid Differentiation of CD133+cells Independent of Cytokine Cocktails
Objective(s): Erythropoiesis is regulated by some extrinsic and intrinsic factors as microRNAs (miRNAs). miRNAs are endogenously small non-coding regulatory RNAs which play vital roles in the variety of cellular fate, critical processes; growth, apoptosis, metabolism, survival of the cells and specially differentiation. Several miRNAs such as miR-16 and miR-451 have been shown to be correlate...
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Radixin, encoded by chromosome 11 (11 exons), is a member of the ERM (ezrin–radixin–moesin) family; it functions as a membrane-cytoskeletal crosslinkers in actin-rich cell surface structures and is thereby thought to be essential for cortical cytoskeleton organization, cell motility, adhesion and proliferation (Hoeflich and Ikura, 2004). ERM proteins display a similar structural organization. T...
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deaths. Much effort has been made to identify key molecules controlling metastasis. However, due to the complicated wiring of the cancer signaling networks, key players initiating cancer metastasis have not been defined. This situation has thwarted target-based drug discovery aimed at preventing cancer metastasis. Regardless of which molecules initiate tumor, cancer cells must be equipped with ...
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ژورنال
عنوان ژورنال: Artificial Cells, Nanomedicine, and Biotechnology
سال: 2019
ISSN: 2169-1401,2169-141X
DOI: 10.1080/21691401.2019.1626404